2,2’-Bipyridine: An efficient organo-catalyst for the synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives

Authors

• Mandana Momenpour Surchani ¹
• Farhad Shirini * ¹
• Hassan Tajik * ¹
• Omid Goli Jolodar ¹

• Department of Chemistry, College of Science, University of Guilan, Rasht, Iran

Abstract

In this work, a highly efficient technique has been documented for the one-pot synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives. This method employs 2,2’-bipyridine as a cost-effective and proficient organo-catalyst. All reactions take place within reasonable reaction periods, yielding favorable to excellent results. The reusability of the catalyst is also investigated during the reactions. Moreover, a rational mechanism was suggested via GC-Mass analysis of the trapped intermediates.

Research Highlights

• 2,2′-bipyridine as an excellent basic catalyst for the synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines in the aqua media.
• Simple procedure, short reaction times, and high yields.
• No column chromatographic separation, commercial availability and recyclability of the catalyst.
• Use of GC-Mass analysis for the confirmation of the proposed mechanism.

Graphical Abstract

Keywords

• 2’-bipyridine
• Pyrano[2
• Organo-catalyst
• Pyrido[2
• One-pot synthesis
• 3-d]pyrimidines
• 2