Iranian Journal of Catalysis (IJC) 2,2’-Bipyridine: An efficient organo-catalyst for the synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives Volume 14 (2024) Issue 3, September 2024 (In Progress) 2024 08 30 2,2’-Bipyridine: An efficient organo-catalyst for the synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives 10.57647/j.ijc.2024.1403.27 EN Mandana Momenpour Surchani Department of Chemistry, College of Science, University of Guilan, Rasht, Iran Farhad Shirini Department of Chemistry, College of Science, University of Guilan, Rasht, Iran 0000-0002-7204-5000 Hassan Tajik Department of Chemistry, College of Science, University of Guilan, Rasht, Iran Omid Goli Jolodar Department of Chemistry, College of Science, University of Guilan, Rasht, Iran Journal Article 2024 08 30 In this work, a highly efficient technique has been documented for the one-pot synthesis of pyrano[2,3-d]pyrimidine and pyrido[2,3-d]pyrimidine derivatives. This method employs 2,2’-bipyridine as a cost-effective and proficient organo-catalyst. All reactions take place within reasonable reaction periods, yielding favorable to excellent results. The reusability of the catalyst is also investigated during the reactions. Moreover, a rational mechanism was suggested via GC-Mass analysis of the trapped intermediates. Research Highlights 2,2′-bipyridine as an excellent basic catalyst for the synthesis of pyrano[2,3-d]pyrimidines and pyrido[2,3-d]pyrimidines in the aqua media. Simple procedure, short reaction times, and high yields. No column chromatographic separation, commercial availability and recyclability of the catalyst. Use of GC-Mass analysis for the confirmation of the proposed mechanism.