Iranian Journal of Catalysis (IJC) Preparation and characterization of a dual acidic Ionic Liquid functionalized Graphene Oxide nanosheets as a Heterogeneous Catalyst for the Synthesis of pyrimido[4,5-b] quinolines in water Volume 13 (2023) IJC Issue 4, December 2023 2024 01 04 Preparation and characterization of a dual acidic Ionic Liquid functionalized Graphene Oxide nanosheets as a Heterogeneous Catalyst for the Synthesis of pyrimido[4,5-b] quinolines in water 10.30495/ijc.2023.1998276.2052 EN Mohanad Yakdhan Saleh Department of Chemistry, College of Education for pure Science, Mosul University, Ministry of High Education and Scientific Research, Mosul, Iraq 0000-0003-2320-5167 Ghufran Th. Sadeek Department of Chemistry, College of Education for pure Science, Mosul University, Ministry of High Education and Scientific Research, Mosul, Iraq Shakir Mahmood Saied Department of Medical Laboratory Techniques, Al-Noor University College, Iraq Journal Article 2024 01 04 Pyrimido[4,5-b]quinolones play a significant role in medicinal chemistry owing to their various biological properties, including antihistaminic, antimalarial, antifungal, anticancer, antioxidant, antiviral, anti-microbial, and anti-inflammatory activities. A dual acidic ionic liquid anchored on graphene oxide nanosheets (GO-Si-Pr-Lysin-SO3H) was provided and characterized using transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetric analysis (TGA), and Fourier transform infrared spectroscopy (FT-IR). The six-step process was utilized to create this catalyst, beginning with graphite powder. This catalyst was capable to develop the one-pot and three components (6-amino-1,3-dimethyluracil, dimedone, and different aromatic aldehydes) synthesis of pyrimido[4,5-b]quinolone derivatives at moderate temperature in water as a green medium (12 derivatives). The results obtained indicated that this method could be an effective approach for synthesizing pyrimido[4,5-b]quinolones with high yields ranging from 86% to 98% in a short reaction time of 15 to 40 minutes. In addition, the pointed catalyst shows reusability and recoverability without remarkable loss of catalytic activity.   Highlights GO-Si-Pr-Lysin-H-SO3H as an efficient heterogeneous catalyst and supported ionic liquid was provided. 12 types of pyrimido[4,5-b]quinolone derivatives using GO-Si-Pr-Lysin-SO3H were prepared. GO-Si-Pr-Lysin-H-SO3H show good catalytic activity for both electron-withdrawing and electron-donating substituents. GO-Si-Pr-Lysin-H-SO3H was characterized and identified using microscopic and spectroscopic techniques. GO-Si-Pr-Lysin-H-SO3H was reused for six catalytic cycle.