Iranian Journal of Catalysis (IJC) Preparation of Fe3O4@APTES-TA-MA covalent organic framework nanocatalyst for the construction of N-amino-2-pyridone analogs Volume 14 (2024) Issue 1, March 2024 2024 03 19 Preparation of Fe3O4@APTES-TA-MA covalent organic framework nanocatalyst for the construction of N-amino-2-pyridone analogs 10.57647/j.ijc.2024.1401.08 EN Amaeneh Mosaffaeirad Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran 0009-0009-9540-190X Masoud Mokhtary Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran 0000-0003-3763-7139 Mohammad Nikpassand Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran 0000-0002-9692-6849 Journal Article 2024 03 19 In this work, an efficient method for the construction of N-amino-2-pyridone analogs was performed using the condensation of aldehyde, malononitrile and cyanoacetohydrazide through Fe3O4@aminopropyltriethoxysilane-terephthaldehyde-melamine (Fe3O4@APTES-TA-MA) as an efficient recyclable magnetic covalent organic framework nanocatalyst in ethanol at reflux conditions. Fe3O4@APTES-TA-MA was characterized via FT-IR, EDS, SEM, TEM, VSM, and TGA methods. The average size of the nanoparticles was found between 40−90 nm. Clean procedure, short reaction time, and high efficiency are some benefits of this protocol. Also, the nanomagnetic catalyst can be reused five times without significant loss of its activity. Highlights: ·      A series of N-amino-2-pyridone analogs were synthesized ·  Fe3O4@APTES-TA-MA covalent organic framework prepared and characterized by different spectroscopic techniques. ·       High yields and easy work-up procedure are some advantages of this protocol. ·      The catalyst is easily recycled by magnetic attraction.