Iranian Journal of Catalysis (IJC) Preparation of Fe3O4@APTES-TA-MA covalent organic framework nanocatalyst for the synthesis of N-amino-2-pyridone analogs 2024 03 13 Preparation of Fe3O4@APTES-TA-MA covalent organic framework nanocatalyst for the synthesis of N-amino-2-pyridone analogs 10.57647/j.ijc.2024.1401.08 EN Journal Article 2024 03 13 In this work, an efficient method for the construction of N-amino-2-pyridone analogs was performed using the condensation of aldehyde, malononitrile and cyanoacetohydrazide through Fe3O4@aminopropyltriethoxysilane-terephthaldehyde-melamine (Fe3O4@APTES-TA-MA) as an efficient recyclable magnetic covalent organic framework nanocatalyst in ethanol at reflux conditions. Fe3O4@APTES-TA-MA was characterized via FT-IR, EDS, SEM, TEM, VSM, and TGA methods. The average size of the nanoparticles was found between 40−90 nm. Clean procedure, short reaction time, and high efficiency are some benefits of this protocol. Also, the nanomagnetic catalyst can be reused five times without significant loss of its activity.