Iranian Journal of Catalysis (IJC) Nanocrystalline TiO2 as an efficient and reusable catalyst for the one-pot synthesis of polyhydroquinolien derivatives via Hantzsch reaction Volume 1 (2011) Issue 2, December 2011 2024 02 03 Nanocrystalline TiO2 as an efficient and reusable catalyst for the one-pot synthesis of polyhydroquinolien derivatives via Hantzsch reaction EN Farhad Shirini Department of Chemistry, College of Science, University of Guilan, Rasht, Iran 0000-0002-7204-5000 Seyyed Vahid Atghia Department of Chemistry, College of Science, University of Guilan, Rasht, I.R. Iran. Meysam Alipour Khoshdel Department of Chemistry, College of Science, University of Guilan, Rasht, zip code 41335, I.R. Iran. Journal Article 2024 02 03 An efficient synthesis of polyhydroquinoline derivatives was reported via four-component coupling reactions of aldehydes, 1,3-dicarbonyl ketones (dimedone or 1,3-cyclohexanedione), ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanocrystalline TiO2 under solvent free conditions. The reported method is mild, rapid and has the advantages such as heterogeneous catalysis, simple work-up procedure, recyclability of the catalyst and purification of products without chromatographic methods.