Iranian Journal of Catalysis (IJC) A green protocol for synthesis of pyran annulated hetrocyclic systems using Na2SO4 as an efficient catalyst Volume 5 (2015) Issue 2, June 2015 2024 02 03 A green protocol for synthesis of pyran annulated hetrocyclic systems using Na2SO4 as an efficient catalyst EN Malek Taher Maghsoodlou Chemistry Department, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran Amin Masoumnia Department of Chemistry, The University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran Mir Rasul Mousavi Department of Chemistry, The University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran Nourollah Hazeri Department of Chemistry, The University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran Jasem Aboonajmi Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran Sayyed Mostafa Habibi-Khorasani Department of Chemistry, The University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran Shiva Kiaee Department of Chemistry, The University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran Journal Article 2024 02 03 Na2SO4 as an inexpensive and effective catalyst has provided a green protocol for the synthesis of tetrahydrobenzo[b]pyran, pyrano[2,3-d]pyrimidinone and dihydropyrano[3,2c]chromene derivatives from the three-component domino reaction of aromatic aldehydes and malononitrile with 4-hydroxycoumarin/ dimedone/ barbituric acid in ethanol/water as a mixture of solvent that, this mixture entirely is green solvent. Products could simply be separated from the catalyst. Using neutral and mild conditions, short reaction time, environmentally benign procedure, high to excellent yields of the products and easy work-up without using column chromatography are the advantages of this method. By virtue of these advantages, sodium sulfate can be used as catalyst in the organic transformations.