Iranian Journal of Catalysis (IJC) Chloroacetic acid-promoted heterocyclic reactions: Efficient preparation of tetrahydropyridines and 2,3-dihydroquinazolin-4(1H)-ones Volume 5 (2015) Issue 3, September 2015 2024 02 03 Chloroacetic acid-promoted heterocyclic reactions: Efficient preparation of tetrahydropyridines and 2,3-dihydroquinazolin-4(1H)-ones EN Malek Taher Maghsoodlou Chemistry Department, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran Nourallah Hazeri Chemistry Department, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran Elham Fereidooni Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran Sajjad Salahi Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran Nasrin Mahmoudabadi Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran Naeime Khorshidi Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran Jasem Aboonajmi Department of Chemistry, College of Sciences, Shiraz University, Shiraz 71454, Iran Mojtaba Lashakri Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran Journal Article 2024 02 03 Facile and versatile procedures have been explored for the synthesis of tetrahydropyridines and 2,3-dihydroquinazolin-4(1H)-ones. These protocols employ the one-pot multi-component condensation of arylaldehydes and aromatic amines with β-keto esters and isatoic anhydride in chloroacetic acid, respectively. The reactions proceeded smoothly to generate the corresponding products in high yield. We have found that the use of chloroacetic acid as catalyst results in a remarkable beneficial effect on the reaction, allowing it to be performed without the need of any co-catalyst, which is the case in other similar reported methodologies. In addition, the preparation of 2,3-dihydro-4(1H)-quinazolinones derivatives from the reaction of arylaldehydes and anthranilamide in the presence of mentioned catalyst is reported.