Iranian Journal of Catalysis (IJC) One-pot three component synthesis of 2-amino-4H-chromenes under green and high efficient conditions Volume 5 (2015) Issue 4, December 2015 2024 02 03 One-pot three component synthesis of 2-amino-4H-chromenes under green and high efficient conditions EN Leila Moradi Department of Organic Chemistry, Faculty of Chemisry, University of Kashan, Kashan, Iran, P.O. Box 8731753153. Mina Zare Faculty of Chemistry, Department of Organic Chemistry, University of Kashan, P.O. Box 87317-51167, Kashan, Iran. Journal Article 2024 02 03 A simple, mild and high efficient procedure for one pot three component synthesis of 2-amino 4-H chromene derivatives was studied. The reaction was performed in water using aryl aldehydes, malononitrile and resorcinol, phloroglucinol or naphthole in the presence of N-methyl D-glucamine (Meglumine) as a green high efficient catalyst. The reaction was studied in thermal, microwave (MW) and ultrasonic (US) conditions. Obtained results show that meglumine, as a green catalyst, has high efficiency in all reaction conditions and the yield of products (in all cases) is high to excellent. Environment friendly solvent and catalyst, short reaction times and high yield products are the advantageous of presented research.