Iranian Journal of Catalysis (IJC) Magnetic nanosphere Fe3O4@SiO2.SnCl4 promoted synthesis of 5-substituted 1H-tetrazoles Volume 7 (2017) Issue 3, September 2017 2024 02 03 Magnetic nanosphere Fe3O4@SiO2.SnCl4 promoted synthesis of 5-substituted 1H-tetrazoles EN Bi Bi Fatemeh Mirjalili Department of Chemistry, College of Science, Yazd University, Yazd, P.O. Box 89195-741, Iran 0000-0002-6588-4041 Hadise Jorsarraie Department of Chemistry, College of Science, Yazd University, Yazd. P.O. Box 89195-741, Iran. Hamidreza Akrami Young Researcher and Elite Club, Yazd Branch, Islamic Azad University, Yazd, Islamic Republic of Iran. Journal Article 2024 02 03 Tetrazoles have many interesting futures and applications in drug and energy industries. 5-Substituted 1H-tetrazoles were synthesized via [2+3] cycloaddition reaction of aryl or alkyl nitriles with sodium azide in the presence of Fe3O4@SiO2.SnCl4 as catalyst in DMF under reflux conditions.  The catalyst was removed from reaction mixture by an external magnet and was reusable for many times without any appreciable loss of its activity. The Fe3O4@SiO2.SnCl4 promotes synthesis of tetrazole in shorter time than other reported catalysts. The obtained tetrazoles were identified by spectroscopic and physical data such as FT-IR, 1HNMR and melting point. Easy workup and reusability of catalyst are some advantages of this protocol.