International Journal of Nano Dimension (Int. J. Nano Dimens.) Nanosized biomaterials for regenerative medicine Volume 9 (2018) Issue 3, August 2018 2024 02 28 Nanosized biomaterials for regenerative medicine EN Raffaele Conte AMES Group Polydiagnostic Center, Via Padre Carmine Fico, 24 80013 Casalnuovo di Napoli (NA), Italy. 0000-0002-6266-4991 Anna Calarco Institute of Agro-Environmental and Forest Biology, National Research Council, Naples, Italy. 0000-0002-1441-7662 Gianfranco Peluso Institute of Agro-Environmental and Forest Biology, National Research Council, Naples, Italy. Journal Article 2024 02 28 This review discusses recent developments in the field of nanosized biomaterials and their use in tissue regeneration approaches. The aim is to provide an overview of the research focused on nanoparticle-based strategies to stimulate regeneration. In particular, nanoparticles improve the regenerative capabilities of biomaterials offering ways to control surface and mechanical properties. Moreover, incorporation of nanoparticles within biomaterials increases cellular adhesion, differentiation and integration of stem cells into the surrounding environment. Finally, the drug delivery capabilities of nanoparticles offer additional possibilities to increase the biological performance of biomaterials. As the development of nanoparticles continues, incorporation of this technology in the field of regenerative medicine will ultimately lead to new tools that can diagnose, track and stimulate the growth of new tissues and organs.