OICC PRESS Sevoflurane postconditioning attenuates hepatic ischemia-reperfusion injury in rats by activating Nrf2/HO-1 signaling pathway Volume 14 (2023) IJIC Issue 2, September 2023 2023 11 16 Sevoflurane postconditioning attenuates hepatic ischemia-reperfusion injury in rats by activating Nrf2/HO-1 signaling pathway 10.57647/j.ijic.2023.1402.08 EN Xia Xu The Affiliated Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315010, China. Kai Zhang The Affiliated Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315010, China. Lihong Hu The Affiliated Lihuili Hospital, Ningbo University, Ningbo, Zhejiang 315010, China. Journal Article 2023 11 16 Objective: To investigate the effect of sevoflurane postconditioning on the levels of Nrf2 expressed in the early stage of hepatic ischemia-reperfusion injury (HIRI) in rats and to explore the possible Mechanism of sevoflurane postconditioning in attenuating HIRI. Methods: 24 S.D. rats were randomly divided into Sham group, Sevoflurane group, HIRI group, and HIRI+Sevoflurane group. The HIRI model was established, and 2% sevoflurane was inhaled for 30 min after restoring the liver blood supply. Results: Comthe compared to the Sham group, the liver from the rats in the HIRI group demonstrated apparent tissue damage, the percentage of TUNEL-positive cells was significantly increased, and the levels of ALT, AST, TNF-α, IL-6, and IL-8 in the serum were significantly elevated (P < 0.01). Moreover, in the HIRI group, Nrf2, HO-1, Bcl-2, SOD, GSH, MDA, and Bax levels were remarkably reduced (P < 0.01). Compared with the HIRI group, the rats in the HIRI+Sevoflurane group presented alleviated liver tissue damage, decreased the ratio of TUNEL positive cells, significantly decreased the levels of TNF-α, ALT, AST, IL-6, and IL-8 in the serum (P < 0.01), among other markers for oxidative stress. Conclusion: Sevoflurane postconditioning may attenuate HIRI in rats by inhibiting the oxidative stress injury of liver cells via activating the Nrf2/HO-1 signaling pathway.

OICC PRESS Clinical study of fire-dragon moxibustion therapy based on Fuyang Tongbi theory in wind-cold-dampness rheumatoid arthritis patients Volume 14 (2023) IJIC Issue 2, September 2023 2023 11 16 Clinical study of fire-dragon moxibustion therapy based on Fuyang Tongbi theory in wind-cold-dampness rheumatoid arthritis patients 10.57647/j.ijic.2023.1402.07 EN Qing Zhang Department of Endocrine Rheumatology, Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, 215600, China. Yu Shao Department of Endocrine Rheumatology, Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, 215600, China. Juan Huang Department of Endocrine Rheumatology, Zhangjiagang Hospital of Traditional Chinese Medicine, Zhangjiagang, Suzhou, Jiangsu, 215600, China. Lijuan Li Department of Nursing, Zhangjiagang Traditional Chinese Medicine Hospital, Zhangjiagang, Suzhou, Jiangsu, 215600, China. Journal Article 2023 11 16 Objective: To probe the clinical value of fire-dragon moxibustion treatment based on Fuyang Tongbi theory in wind-colddampness rheumatoid arthritis (R.A.) patients. Methods: 80 patients with joint pain were selected, including 40 in the fire-dragon moxibustion group and 40 in the conventional group. Patients in the traditional group accepted non-steroidal anti-inflammatory drugs and other Chinese and Western drugs according to the patient’s specific situation. Based on the treatment in the conventional group, fire-dragon moxibustion treatment based on Fuyang Tongbi theory was given to patients in the fire-dragon moxibustion group. Results: The total effective rate in the fire-dragon moxibustion group was elevated compared to the conventional group (P < 0.05). After treatment, VAS and WOMAC scores in both groups declined, and those in the fire-dragon moxibustion group were lessened than those in the conventional group (P < 0.05). The serum levels of TNF-α, IL-6, hs-CRP, as R.F. in both groups were reduced (P < 0.05), and their stories in the fire-dragon moxibustion group were lower in comparison with the conventional group (P < 0.05). The quality of life scores in the fire-dragon moxibustion group was better compared to the traditional group (P < 0.05). Conclusion: The use of fire-dragon moxibustion in treating wind-cold-dampness R.A. based on Fuyang Tongbi theory is effective, which can reduce the pain symptoms and inflammatory reactions of bone and joints in patients, improve joint function, promote the quality of life, and has good safety, which can provide a reference for clinical treatment of wind-cold-dampness R.A.

OICC PRESS Clinical efficacy and nursing intervention of ceftazidime tazobactam sodium combined with levofloxacin in treating heart failure complicated with pulmonary infection in elderly patients Volume 14 (2023) IJIC Issue 2, September 2023 2023 11 16 Clinical efficacy and nursing intervention of ceftazidime tazobactam sodium combined with levofloxacin in treating heart failure complicated with pulmonary infection in elderly patients 10.57647/j.ijic.2023.1402.06 EN Sicong Wang Department of Infectious diseases, Beijing Jishuitan Hospital, Beijing 100035, China. Chengdong Sun Department of Infectious diseases, Beijing Jishuitan Hospital, Beijing 100035, China. Yan Wang Department of Infectious diseases, Beijing Jishuitan Hospital, Beijing 100035, China. Jing Ma Department of Cardiology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, Chinese People's Liberation Army General Hospital, Beijing 100036, China. Journal Article 2023 11 16 This study aims to probe the clinical efficacy of the nursing intervention of ceftazidime tazobactam sodium combined with Levofloxacin in treating heart failure complicated with lung infection in elderly patients. Patients in the control group (n = 59) accepted ceftazidime tazobactam sodium injection (3:1). Patients in the observation group (n = 59) were given levofloxacin hydrochloride injection based on the control group. Compared with the control group, the total effective rate of the observation group was elevated (χ2 = 5.94, P < 0.05), levels of inflammatory factors interleukin-4, interleukin-6, and tumor necrosis factor-alpha were lessened (P < 0.05), left ventricular end-systolic diameter together with left ventricular end-diastolic dimension levels were declined (P < 0.05), left ventricular ejection fraction was decreased (P < 0.05), the clearance rate of pathogenic bacteria was higher (P < 0.05), the occurrence of adverse reactions was lessened (P < 0.05). No difference was discovered in the satisfaction rate between both groups (χ2 = 3.01, P > 0.05). To summarize, Ceftazidime, tazobactam sodium, and Levofloxacin can decline inflammatory factor levels in elderly patients with HF and lung infection. It can effectively correct the condition of body infection and is conducive to improving bacterial clearance rate without increasing adverse reactions.

OICC PRESS Influence of Zhigancao decoction on chronic heart failure combined with depression Volume 14 (2023) IJIC Issue 2, September 2023 2023 10 11 Influence of Zhigancao decoction on chronic heart failure combined with depression 10.57647/j.ijic.2023.1402.05 EN Ying Wang Department of Chinese Medicine, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China. Jun Wang Department of the Office of Academic Research, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China. Wang Lv Department of Chinese Medicine, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China. Hu Chen Department of Chinese Medicine, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China. Yang Zhang Department of Chinese Medicine, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China. Qian Yang Department of Chinese Medicine, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China. Xiaoli Ma Department of the Fifth Cardiology, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China. Run Guo Department of the Fifth Cardiology, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China. Qianyu Zhang Department of the Fifth Cardiology, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China. Journal Article 2023 10 11 Objective: To probe the impact of Zhigancao decoction on chronic heart failure (CHF) combined with Depression. Methods: A total of 122 CHF patients combined with Depression who were treated in our hospital treated from March 2020 to October 2022 were chosen for this research. The patients were separated into two groups using the different treatments: 60 cases in the control group (CG) received conventional Western medicine treatment, and 62 points in the observation group (OG) adopted Zhigancao decoction based on the CG. The total effective rate, TCM symptoms and signs scores, and levels of NT-proBNP, hs-CRP and MMP-9, LVEF, PHQ-9, SDS, and MLHF in both groups were compared. Results: After therapy, the total effective rate of patients in the OG was elevated relative to the CG (χ2=6.50, P<0.05), the scores of TCM symptoms together with signs in the OG were lower relative to the CG (P<0.05). NT-pro-BNP, hs-CRP together, with MMP-9 levels in the OG were lower relative to the CG (P<0.05), was no difference and discovered in LVEF between both groups (P>0.05), PHQ-9 together with SDS scores in the OG were reduced relative to the CG (P<0.05). MLHF scores in the OG were higher than the CG (P<0.05). Conclusion: Based on Western medicine therapy, Zhigancao decoction can relieve the clinical symptoms and observation indicators of CHF patients complicated with Depression, which is valuable for clinical Use.